ROCK1 anticorps (Internal Region)
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- Antigène Voir toutes ROCK1 Anticorps
- ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat, Singe
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ROCK1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Fonction
- Rock-1 is a protein encoded by the ROCK1 gene which is approximately 158,1 kDa. Rock-1 is localised to the cytoplasm, cell membrane and Golgi apparatus membrane. It is involved in blood-brain barrier and immune cell transmigration, development Slit-Robo signalling and activation of cAMP-dependent PKA. It is a serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. Rho regulates formation of focal adhesions and stress fibres of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. It is also involved in the regulation of smooth muscle contraction, actin cytoskeleton organization, stress fibre and focal adhesion formation. Rock-1 is expressed in blood platelets. Mutations in the ROCK1 gene may result in multiple sclerosis and corticobasal degeneration. STJ95527 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Rock-1 protein.
- Specificité
- Rock-1 Polyclonal Antibody detects endogenous levels of Rock-1 protein.
- Attributs du produit
- Rabbit polyclonal to Rock-1.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogène
- Synthesized peptide derived from human Rock-1.
- Isotype
- IgG
- Top Product
- Discover our top product ROCK1 Anticorps primaire
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- Indications d'application
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WB 1:500-1:2000
IHC 1:100-1:300
ICC 1:200-1:1000
ELISA 1:20000 - Commentaires
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Detected in blood platelets.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Antigène
- ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
- Autre désignation
- Rock-1 (ROCK1 Produits)
- Synonymes
- anticorps LOC100229794, anticorps CG9774, anticorps DROK, anticorps DRhk, anticorps DRok, anticorps Dmel\\CG9774, anticorps Drok, anticorps ROCK, anticorps ROCK-1, anticorps ROCK1, anticorps ROK, anticorps ROKalpha/beta, anticorps Rhk, anticorps RhoK, anticorps Rock, anticorps Rok, anticorps dROK, anticorps dRok, anticorps drok, anticorps 1110055K06Rik, anticorps Rock-I, anticorps P160Rock, anticorps ROCK-I, anticorps P160ROCK, anticorps p160ROCK, anticorps Rho associated coiled-coil containing protein kinase 1, anticorps Rho kinase, anticorps Rho-associated coiled-coil containing protein kinase 1, anticorps Rho-associated, coiled-coil containing protein kinase 1, anticorps ROCK1, anticorps Rok, anticorps Rock1, anticorps rock1
- Poids moléculaire
- 160 kDa
- ID gène
- 6093
- UniProt
- Q13464
- Pathways
- Dynamique des Microtubules, Signalisation WNT, M Phase, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling
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