ETV1 anticorps

N° du produit ABIN6291698

Détail du produit anti-ETV1 anticorps

Antigène: ETV1 (Ets Variant 1 (ETV1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ETV1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Affinity purification

Immunogène: Recombinant protein of human ETV1

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50 - 1:200
IF 1:50 - 1:200

Commentaires:

Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20C. Avoid freeze / thaw cycles.

Détails sur ETV1

Antigène: ETV1 (Ets Variant 1 (ETV1))

Autre désignation: ETV1 (ETV1 Produits)

Synonymes: anticorps er81, anticorps XER81, anticorps MGC75591, anticorps ER81, anticorps Etsrp81, anticorps ETS variant 1, anticorps ets variant 1, anticorps ETS variant 1 S homeolog, anticorps etv1, anticorps ETV1, anticorps Etv1, anticorps etv1.S

Sujet: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire: 55.131 kDa

ID gène: 2115

UniProt: P50549