EGFR anticorps

N° du produit ABIN6296699

L’anticorps anti-EGFR Monoclonal Souris est utilisé pour la détection de EGFR dans des échantillons de Humain. Il a été validé pour FACS, IP, AP, Func, Inhibition, in vivo, Act et ProA.

Aperçu rapide pour EGFR anticorps (ABIN6296699)

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EGFR est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Affinity Purification (AP), Functional Studies (Func), Blocking Antibody (Inhibition), In vivo Studies (in vivo), Activation (Act), Proliferation Assay (ProA)

Détail du produit anti-EGFR anticorps

Fonction: Mouse anti-Human EGF Receptor Antibody [Sodium Azide Free]

Specificité: Cell surface

Purification: Microsomes from A431 cells were used as the immunogen for this antibody.

Immunogène: Microsomes from A431 cells were used as the immunogen for this antibody.

Information d'application

Indications d'application: Functional Activity (Inhibition): antibody blocks EGF receptor activation, inhibits A431 cell proliferation, arrests tumor growth in vivo, affinity purification
IP: 1-2 μg/500 μg protein lysate
FACS: 0.5-1 μg/million cells

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur EGFR

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Autre désignation: Epidermal growth factor receptor

Sujet:

Target Description: This antibody reacts with the extracellular domain of EGF receptor and blocks the EGF/TGFa  induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGF receptor.  < a href=../search_result.php?search_txt=egfr>EGFR  is type I receptor tyrosine kinase with sequence homology to  < a href=../search_result.php?search_txt=erbb2>ErbB2, -3 -4 or  < a href=../search_result.php?search_txt=her2>HER2, -3 -4. It binds to Epidermal Growth Factor (EGF),  < a href=../search_result.php?search_txt=TGFa>Transforming Growth Factor-a (TGFa), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.

Gene Symbol: EGFR///ERBB///ERBB1///HER1

ID gène: 1956

UniProt: P00533

Pathways: Signalisation NF-kappaB, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins