TLR4 anticorps

N° du produit ABIN6297482

L’anticorps anti-TLR4 Monoclonal Souris est utilisé pour la détection de TLR4 dans des échantillons de Humain, Rat, Chien, Porc, Cobaye et Singe. Il a été validé pour FACS, IHC, IF et Func.

Aperçu rapide pour TLR4 anticorps (ABIN6297482)

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Reactivité: Humain, Rat, Chien, Porc, Cobaye, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TLR4 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF), Functional Studies (Func)

Détail du produit anti-TLR4 anticorps

Fonction: Mouse anti-Human/Monkey/Pig/Dog/Rat/Guinea Pig TLR4 Antibody (Toll Like Receptor 4) [Sodium Azide Free]

Specificité: Cell surface

Purification: Recombinant human protein was used as the immunogen for the TLR4 antibody.

Immunogène: Recombinant human protein was used as the immunogen for the TLR4 antibody.

Information d'application

Indications d'application: Functional Activity (Order SAF formulation)
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur TLR4

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Autre désignation: Toll-like receptor 4

Sujet:

Target Description: This mAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Symbol: TLR4

ID gène: 7099

UniProt: O00206

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins