EGFR anticorps

N° du produit ABIN6297747

Cet anticorps anti-EGFR est un anticorps Souris Monoclonal détectant EGFR dans IF, FACS et IHC (fp). Adapté pour Humain.

Aperçu rapide pour EGFR anticorps (ABIN6297747)

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EGFR est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-EGFR anticorps

Fonction: Mouse anti-Human EGFR Antibody [Sodium Azide Free]

Specificité: Cell surface

Purification: The immunizing protein for this antibody was recombinant human EGFR.

Immunogène: The immunizing protein for this antibody was recombinant human EGFR.

Information d'application

Indications d'application: IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
FACS: 0.5-1 μg/million cells in 0.1ml
IF: 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur EGFR

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Autre désignation: Epidermal growth factor receptor

Sujet:

Target Description: This antibody recognizes a protein of 170 kDa, identified as EGFR.  < a href=../search_result.php?search_txt=egfr>EGFR  is type I receptor tyrosine kinase with sequence homology to  < a href=../search_result.php?search_txt=erbb2>ErbB2, -3 -4 or  < a href=../search_result.php?search_txt=her2>HER2, -3 -4. It binds to Epidermal Growth Factor (EGF),  < a href=../search_result.php?search_txt=TGFa>Transforming Growth Factor-a  (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head/neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Gene Symbol: EGFR///ERBB///ERBB1///HER1

ID gène: 1956

UniProt: P00533

Pathways: Signalisation NF-kappaB, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins