SHC1 anticorps

N° du produit ABIN6298167

Cet anticorps anti-SHC1 Polyclonal Lapin (ABIN6298167) détecte spécifiquement SHC1. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SHC1 anticorps (ABIN6298167)

Antigène: SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHC1 est non-conjugé

Application: Veuillez nous consulter SVP

Détail du produit anti-SHC1 anticorps

Fonction: Rabbit Anti-Shc (Ab-349) Antibody,

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur SHC1

Antigène: SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))

Autre désignation: Shc

Sujet:

Target Description: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Gene Symbol: SHC1

ID gène: 6464

UniProt: P29353

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2