NSMCE2 anticorps

N° du produit ABIN631769

Détail du produit anti-NSMCE2 anticorps

Antigène: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NSMCE2 est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purified

Immunogène: NSMCE2 antibody was raised using a synthetic peptide corresponding to a region with amino acids KFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDE

Information d'application

Indications d'application: WB: 1 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

NSMCE2 Blocking Peptide, catalog no. 33R-4372, is also available for use as a blocking control in assays to test for specificity of this NSMCE2 antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of NSMCE2 antibody in PBS

Concentration: Lot specific

Buffer: PBS

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Détails sur NSMCE2

Antigène: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Autre désignation: NSMCE2 (NSMCE2 Produits)

Synonymes: anticorps 1110014D18Rik, anticorps AI661537, anticorps RGD1305156, anticorps C8orf36, anticorps MMS21, anticorps NSE2, anticorps ZMIZ7, anticorps Non-SMC element 2, anticorps NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase, anticorps NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog, anticorps Smc5-6 complex non-SMC subunit 2, anticorps Nsmce2, anticorps NSMCE2, anticorps nsmce2.L, anticorps nse2

Sujet: NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Poids moléculaire: 28 kDa (MW of target protein)