COL25A1 anticorps (AA 155-169)

N° du produit ABIN636294

Détail du produit anti-COL25A1 anticorps

Antigène: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Épitope: AA 155-169

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COL25A1 est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity chromatography purified

Immunogène: CLACP antibody was raised in rabbit using AA 155-169 [KGEQGDQGPRMVFPK] of the NC2-2 region of human and mouse CLAC-P as the immunogen.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500
Optimal conditions should be determined by the investigator.

Commentaires:

This antibody producess bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy.

Restrictions: For Research Use only

Stockage

Concentration: Lot specific

Buffer: Affinity purified IgG supplied in PBS with 0.02 % NaN3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Détails sur COL25A1

Antigène: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Autre désignation: CLACP (COL25A1 Produits)

Synonymes: anticorps COL25A1, anticorps AMY, anticorps CLAC, anticorps CLAC-P, anticorps CLACP, anticorps 2700062B08Rik, anticorps collagen type XXV alpha 1 chain, anticorps collagen, type XXV, alpha 1, anticorps COL25A1, anticorps col25a1, anticorps Col25a1

Sujet: The 9D2 antigen isolated from senile plaque amyloid was identified as collagen-like Alzheimer amyloid plaque component (CLAC), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bind to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.