FGFR1 anticorps (AA 285-314)

N° du produit ABIN653771

L’anticorps anti-FGFR1 Polyclonal Lapin est utilisé pour la détection de FGFR1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour FGFR1 anticorps (AA 285-314) (ABIN653771)

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB10987

Détail du produit anti-FGFR1 anticorps

Épitope: AA 285-314

Homologie: C, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from human FGFR1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur FGFR1

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Autre désignation: FGFR1

Sujet: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

Poids moléculaire: 91868

ID gène: 2260

NCBI Accession: NP_001167534, NP_001167535, NP_001167536, NP_001167537, NP_001167538, NP_056934, NP_075593, NP_075594, NP_075598

UniProt: P11362

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins