CYP2B6 anticorps (AA 235-263)

N° du produit ABIN655056

Détail du produit anti-CYP2B6 anticorps

Antigène: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Épitope: AA 235-263

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP2B6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CYP2B6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CYP2B6.

Clone: RB16992

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:25. WB: 1:2000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-CYP2B6 (ABIN655056)

Okamatsu, Komatsu, Ono, Inoue, Uchide, Onaga, Endoh, Kitazawa, Hiraga, Uno, Teraoka: "Characterization of feline cytochrome P450 2B6." dans: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 2, pp. 93-102, (2017) (PubMed).

Hlavá?, Brynychová, Václavíková, Ehrlichová, Vrána, Pecha, Trnková, Kodet, Mrhalová, Kubá?ková, Gat?k, Vážan, Sou?ek: "The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients." dans: Medicine, Vol. 93, Issue 28, pp. e255, (2014) (PubMed).

Détails sur CYP2B6

Antigène: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Autre désignation: CYP2B6 (CYP2B6 Produits)

Synonymes: anticorps CPB6, anticorps CYP2B, anticorps CYP2B7, anticorps CYP2B7P, anticorps CYPIIB6, anticorps EFVM, anticorps IIB1, anticorps P450, anticorps CPF3, anticorps CYP4F, anticorps LTB4H, anticorps CYP2B30, anticorps CYP2B11, anticorps CYPIIB11, anticorps 21-OH, anticorps 21OH, anticorps 21OHA, anticorps 21OHB, anticorps CYP21OH-A, anticorps Cyp21, anticorps Cyp21-ps1, anticorps Cyp21B, anticorps Cyp21a2-ps, anticorps Cyp21a2ps, anticorps Oh21-1, anticorps Oh21-2, anticorps CYP2B6, anticorps cytochrome P450 family 2 subfamily B member 6, anticorps cytochrome P450 family 4 subfamily F member 3, anticorps cytochrome P450, family 2, subfamily B, polypeptide 6, anticorps cytochrome P450 family 2 subfamily B member 6 L homeolog, anticorps cytochrome P450 2B11, anticorps cytochrome P450, family 21, subfamily a, polypeptide 1, anticorps cytochrome P450 subfamily 2B, anticorps cytochrome P450 2B11-like, anticorps CYP2B6, anticorps CYP4F3, anticorps cyp2b6.L, anticorps Cyp21a1, anticorps LOC100068603

Sujet: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described, however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Poids moléculaire: 56278

ID gène: 1555

NCBI Accession: NP_000758

UniProt: P20813