RECQL2 anticorps (AA 787-816)

N° du produit ABIN656017

Cet anticorps Lapin Polyclonal détecte spécifiquement RECQL2 dans WB, FACS et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour RECQL2 anticorps (AA 787-816) (ABIN656017)

Antigène: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RECQL2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB17383

Détail du produit anti-RECQL2 anticorps

Épitope: AA 787-816

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 787-816 amino acids from the Central region of human WRN.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:100. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-RECQL2 (ABIN656017)

Kawakubo-Yasukochi, Morioka, Hazekawa, Yasukochi, Nishinakagawa, Ono, Kawano, Nakamura, Nakashima: "miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment." dans: Molecular carcinogenesis, Vol. 57, Issue 2, pp. 295-302, (2018) (PubMed).

Détails sur RECQL2

Antigène: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Autre désignation: WRN

Sujet: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Poids moléculaire: 162461

ID gène: 7486

NCBI Accession: NP_000544

UniProt: Q14191

Pathways: Réparation de l'ADN