TRAF2 anticorps

N° du produit ABIN6566707

Cet anticorps Lapin Polyclonal détecte spécifiquement TRAF2 dans WB et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour TRAF2 anticorps (ABIN6566707)

Antigène: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAF2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-TRAF2 anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human TRAF2

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000 IF 1:20 - 1:100

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TRAF2

Antigène: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Autre désignation: TRAF2

Sujet:

Synonyms: E3 ubiquitin-protein ligase TRAF2,MGC:45012,OTTHUMP00000022625,OTTHUMP00000064745,TNF receptor associated factor 2,TNF receptor-associated factor 2,TNF receptor-associated protein,TRAF 2,TRAF2,TRAF2,TRAP 3,TRAP,TRAP3,Tumor necrosis factor type 2 receptor associated protein 3,Tumor necrosis factor type 2 receptor-associated protein 3

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Poids moléculaire:

Observed_MW: 54kDa

Calculated_MW: 53kDa/54kDa/55kDa/61kDa

ID gène: 7186

UniProt: Q12933

Pathways: Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins