This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This STARD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human STARD5.
anticorps STARD5, anticorps MGC131265, anticorps DKFZp469N2125, anticorps 2310058G22Rik, anticorps AI607880, anticorps D7Ertd152e, anticorps RGD1561783, anticorps StAR related lipid transfer domain containing 5, anticorps StAR related lipid transfer domain containing 5 S homeolog, anticorps StAR-related lipid transfer (START) domain containing 5, anticorps StAR-related lipid transfer domain containing 5, anticorps STARD5, anticorps stard5.S, anticorps Stard5
Sujet
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1, MIM 184756) and by liver X receptors (e.g., LXRA, MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR, MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]).