CRYAB anticorps

N° du produit ABIN5965510

Détail du produit anti-CRYAB anticorps

Antigène: CRYAB (Crystallin, alpha B (CRYAB))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRYAB est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant protein of human CRYAB

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CRYAB

Antigène: CRYAB (Crystallin, alpha B (CRYAB))

Autre désignation: Crystallin-alpha B (CRYAB Produits)

Synonymes: anticorps CMD1II, anticorps CRYA2, anticorps CTPP2, anticorps CTRCT16, anticorps HSPB5, anticorps MFM2, anticorps Crya-2, anticorps Crya2, anticorps HspB5, anticorps AACRYA, anticorps CRYAB, anticorps cryab, anticorps cryab2, anticorps wu:fe37f08, anticorps zgc:91937, anticorps crystallin alpha B, anticorps crystallin, alpha B, anticorps hypothetical protein, anticorps crystallin, alpha B, a, anticorps crystallin, alpha B, b, anticorps CRYAB, anticorps Cryab, anticorps ZK1128.7, anticorps cryaba, anticorps cryabb

Sujet:

Synonyms: AACRYA,Alpha B crystallin,Alpha crystallin B chain,Alpha(B)-crystallin,Alpha-crystallin B chain,CRYA2,Cryab,CRYAB,Crystallin alpha B,Crystallin alpha polypeptide 2,CTPP2,Heat shock 20 kD like protein,Heat shock protein beta 5,Heat shock protein beta-5,HspB5,Renal carcinoma antigen NY REN 27,Renal carcinoma antigen NY-REN-27,Rosenthal fiber component

Background: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.

Poids moléculaire:

Observed_MW: 20kDa

Calculated_MW: 20kDa

ID gène: 1410

UniProt: P02511