MLL/KMT2A anticorps

N° du produit ABIN6568337

Détail du produit anti-MLL/KMT2A anticorps

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLL/KMT2A est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant Protein of human KMT2A

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MLL/KMT2A

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Autre désignation: KMT2A (MLL Produits)

Synonymes: anticorps ALL-1, anticorps CXXC7, anticorps HRX, anticorps HTRX1, anticorps MLL, anticorps MLL/GAS7, anticorps MLL1A, anticorps TET1-MLL, anticorps TRX1, anticorps WDSTS, anticorps 6430520K01, anticorps All1, anticorps Cxxc7, anticorps Mll, anticorps Mll1, anticorps mKIAA4050, anticorps lysine methyltransferase 2A, anticorps lysine (K)-specific methyltransferase 2A, anticorps KMT2A, anticorps Kmt2a

Sujet:

Synonyms: ALL-1,ALL1,C-terminal cleavage product of 180 kDa,CXXC-type zinc finger protein 7,CXXC7,HRX,HTRX1,KMT2A,Lysine N-methyltransferase 2A,Mll,MLL cleavage product C180,MLL1,MLL1,MLL1A,N-terminal cleavage product of 320 kDa,p180,p320,Trithorax-like protein,TRX1,Zinc finger protein HRX

Background: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Poids moléculaire:

Observed_MW: 180kDa

Calculated_MW: 427kDa/431kDa/432kDa

ID gène: 4297

UniProt: Q03164

Pathways: L'effet Warburg