Uromodulin anticorps
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- Antigène Voir toutes Uromodulin (UMOD) Anticorps
- Uromodulin (UMOD)
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Uromodulin est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogène
- Recombinant protein of human UMOD
- Isotype
- IgG
- Top Product
- Discover our top product UMOD Anticorps primaire
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- Indications d'application
- WB 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- Uromodulin (UMOD)
- Autre désignation
- UMOD (UMOD Produits)
- Synonymes
- anticorps ADMCKD2, anticorps FJHN, anticorps HNFJ, anticorps HNFJ1, anticorps MCKD2, anticorps THGP, anticorps THP, anticorps urehr4, anticorps uromodulin, anticorps UMOD, anticorps Umod
- Sujet
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Synonyms: ADMCKD2,FJHN,HNFJ,HNFJ1,MCKD2,medullary cystic kidney disease 2 (autosomal dominant),Tamm Horsfall glycoprotein,Tamm Horsfall urinary glycoprotein,Tamm-Horsfall urinary glycoprotein,THGP,THP,Umod,Urehd1,urehr4,UROM,uromodulin (uromucoid,Tamm-Horsfall glycoprotein),Uromodulin,Uromodulin,secreted form
Background: The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
- Poids moléculaire
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Observed_MW: 70kDa
Calculated_MW: 55kDa/66kDa/67kDa/69kDa/73kDa
- ID gène
- 7369
- UniProt
- P07911
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