POLR3B anticorps (N-Term)

N° du produit ABIN657740

Détail du produit anti-POLR3B anticorps

Antigène: POLR3B (Polymerase (RNA) III (DNA Directed) Polypeptide B (POLR3B))

Épitope: AA 330-359, N-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLR3B est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This POLR3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-359 amino acids from the N-terminal region of human POLR3B.

Clone: RB32825

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: POLR3B Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur POLR3B

Antigène: POLR3B (Polymerase (RNA) III (DNA Directed) Polypeptide B (POLR3B))

Autre désignation: POLR3B (POLR3B Produits)

Synonymes: anticorps RGD1565311, anticorps C128, anticorps HLD8, anticorps RPC2, anticorps 2700078H01Rik, anticorps A330032P03Rik, anticorps C85372, anticorps RNA polymerase III subunit B, anticorps polymerase (RNA) III (DNA directed) polypeptide B, anticorps Polr3b, anticorps POLR3B

Sujet: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.

Poids moléculaire: 127785

ID gène: 55703

NCBI Accession: NP_001154180, NP_060552

UniProt: Q9NW08