AKT2 anticorps

N° du produit ABIN659024

Il existe 2+ publications pour ce produit. L’anticorps anti-AKT2 Monoclonal Souris est utilisé pour la détection de AKT2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IF et IHC (p).

Aperçu rapide pour AKT2 anticorps (ABIN659024)

Antigène: AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AKT2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 148CT5-4-1-4

Détail du produit anti-AKT2 anticorps

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This AKT2 monoclonal antibody is generated from mouse immunized with AKT2 recombinant protein.

Isotype: IgG1

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:500-1:2000. WB: 1:100~500. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-AKT2 (ABIN659024)

Sun, Zhang, Wang, Jin, Jia, Yu, Chen: "MiRNA-615-5p functions as a tumor suppressor in pancreatic ductal adenocarcinoma by targeting AKT2." dans: PLoS ONE, Vol. 10, Issue 4, pp. e0119783, (2015) (PubMed).

Cui, Lin, Zuo, Zhang, Dong, Hu, Luo, Chen, Lu: "AKT2-knockdown suppressed viability with enhanced apoptosis, and attenuated chemoresistance to temozolomide of human glioblastoma cells in vitro and in vivo." dans: OncoTargets and therapy, Vol. 8, pp. 1681-90, (2015) (PubMed).

Détails sur AKT2

Antigène: AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))

Autre désignation: AKT2

Sujet: AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.

Poids moléculaire: 55769

ID gène: 208

NCBI Accession: NP_001617

UniProt: P31751

Pathways: Signalisation PI3K-Akt, Signalisation RTK, AMPK Signaling, Signalisation TLR, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Hepatitis C, VEGF Signaling