Amyloid Oligomers anticorps

N° du produit ABIN6655723

Détail du produit

Antigène: Amyloid Oligomers

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Réactivité croisée: Humain, Souris

Purification: Anti-Amyloid Oligomers (A11) Antibody was purified by Protein A chromatography. A BLAST analysis was used to suggest cross-reactivity with Amyloid Oligomers (A11) from Eukaryotes, Human, Mouse, and Rat based on 100% homology with the immunizing sequence. Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils. Cross-reactivity with Amyloid Oligomers (A11) from other sources has not been determined.

Immunogène:

Immunogen: Amyloid Oligomers (A11) Antibody was produced from whole rabbit serum prepared by repeated immunizations with synthetic molecular mimic of soluble oligomers.

Immunogen Type: Peptide

Isotype: IgG

Information d'application

Indications d'application:

Immunohistochemistry Dilution: 1:1000-10,000

Application Note: Anti-Amyloid Oligomers (A11) Antibody is suitable for use in IP, IF microscopy, IHC, ELISA, WB, and Dot blot. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: 1:1000

ELISA Dilution: 0.1-10 μg/mL

Western Blot Dilution: 1:1000

IF Microscopy Dilution: User Optimized

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

0.09 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Référence

Peng, Achariyar, Li, Liao, Mestre, Hitomi, Regan, Kasper, Peng, Ding, Benveniste, Nedergaard, Deane: "Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease." dans: Neurobiology of disease, Vol. 93, pp. 215-25, (2018) (PubMed).

Détail du antigène

Antigène: Amyloid Oligomers

Autre désignation: Amyloid Oligomers (A11)

Sujet:

Synonyms: Rabbit Anti-Amyloid Oligomer αβ Antibody, Rabbit Anti-Amyloid Oligomer alpha beta Antibody, Rabbit Anti-Amyloid Oligomers A11 Antibody, Amyloid beta A4 protein, Amyloid Oligomer AlphaBeta Antibody, APP Antibody, ABPP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, A4, AD1

Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres. These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease. Anti-Amyloid Oligomers A11 Antibody is useful for researchers interested in Neuroscience research.

Gene Name: APP

ID gène: 351

NCBI Accession: NM_000484

UniProt: P05067