MEK1 anticorps (pSer218, pSer222)

N° du produit ABIN6655972

N° du produit (Fournisseur): 600-401-c84

L’anticorps anti-MEK1 Polyclonal Lapin est utilisé pour la détection de MEK1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour MEK1 anticorps (pSer218, pSer222) (ABIN6655972)

Antigène: MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MEK1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MEK1 anticorps

Épitope: pSer218, pSer222

N° du produit (Fournisseur): 600-401-c84

Fournisseur: Rockland

Fonction: MEK1/2 phosphoS218/pS222 Antibody

Réactivité croisée (Details): Anti-MEK 1/2 pS218/pS222 antibodies is directed against MEK protein phosphorylated at pS218 and pS222.

Purification: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Immunogène: Anti-MEK 1/2 pS218/pS222 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser218/222 conjugated to KLH.

Isotype: IgG

Information d'application

Indications d'application: Optional[Neutralization_Dilution]: 1:1000

Commentaires:

Anti-MEK 1/2 pS218/pS222 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions of reactivity should be optimized by the end user. Expect a band of approximately 45 kDa in size corresponding to the MEK 1/2 proteins phosphorylated at Ser218/222.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur MEK1

Antigène: MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Autre désignation: MAP2K1/MAP2K2

Sujet:

Synonyms: Dual specificity mitogen-activated protein kinase kinase 1, MAPKK 1, ERK activator kinase 1,MAPK/ERK kinase 1

Background: MEK 1/2 pS218/pS222 antibodies detect MEK 1. MAP Kinase Kinase, also known as MKK or MEK, is an integral component of the MAP kinase cascade that regulates cell growth and differentiation. This pathway also plays a key role in synaptic plasticity in the brain. Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase. Therefore, MEK1/2 pS218/pS222 antibody is ideal for investigators involved in Neuroscience, Cell Signaling and Cancer Research

Gene Name: MAP2K1/2

ID gène: 5604

NCBI Accession: NP_002746

UniProt: Q02750

Pathways: Signalisation MAPK, Signalisation RTK, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling