5HT1B Receptor anticorps

N° du produit ABIN6658050

N° du produit (Fournisseur): 200-401-i11

Cet anticorps Lapin Polyclonal détecte spécifiquement 5HT1B Receptor dans WB. Il présente une réactivité envers Rat.

Aperçu rapide pour 5HT1B Receptor anticorps (ABIN6658050)

Antigène: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 5HT1B Receptor est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-5HT1B Receptor anticorps

N° du produit (Fournisseur): 200-401-i11

Fournisseur: Rockland

Fonction: Serotonin Receptor 1B Antibody

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with Anti-Serotonin Receptor 1B from human, mouse and rat based on 100 % homology with the immunizing sequence.

Purification: Anti-Serotonin Receptor 1B Antibody was purified by Protein G chromatography.

Immunogène: Serotonin Receptor 1B Antibody was produced from whole rabbit serum prepared by repeated immunizations with a mixture of synthetic peptides corresponding to two internal amino acid sequences in rat 5-HT1BR protein.

Isotype: IgG

Information d'application

Indications d'application: Optional[Neutralization_Dilution]: 1-2 μg/mL

Commentaires:

Anti-Serotonin Receptor 1B antibody is tested for use in WB and suitable in IF/ICC. Expect a band approximately 40kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

Preservative: 0.05 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur 5HT1B Receptor

Antigène: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Autre désignation: Serotonin Receptor 1B

Sujet:

Synonyms: 5ht1b

Background: Anti-Serotonin Receptor 1B antibody detects rat Serotonin Receptor 1B. Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. The in situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei. Anti-Serotonin Receptor 1B antibody is ideal for investigators involved in neurobiology.

Gene Name: Htr1b

ID gène: 25075

NCBI Accession: NP_071561

UniProt: P28564

Pathways: Signalistation JAK/STAT, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, S100 Proteins