p21 anticorps (AA 101-164)

N° du produit ABIN672606

Cité dans 5 publications. Cet anticorps anti-p21 Polyclonal Lapin (ABIN672606) détecte spécifiquement p21 dans IHC (p), IF (p), IF (cc) et IHC (fro). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour p21 anticorps (AA 101-164) (ABIN672606)

Antigène: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p21 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-p21 anticorps

Épitope: AA 101-164

Fonction: CDKN1A/p21 Polyclonal Antibody

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CDKN1A

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-p21 (ABIN672606)

Jiang, Miao, Xiao, Zhang, Hu: "DAPT in the control of human hair follicle stem cell proliferation and differentiation." dans: Post?py dermatologii i alergologii, Vol. 31, Issue 4, pp. 201-6, (2014) (PubMed).

Wu, Wang, Zong, Chen, Wang, Xu, Cui: "Simultaneous evaluation of p53 and p21 expression level for early cancer diagnosis using SERS technique." dans: The Analyst, Vol. 138, Issue 12, pp. 3450-6, (2013) (PubMed).

Li, Dai, Ye, Wang, Xiao, Zheng, Chen, Luo, Liu: "Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition." dans: Cancer cell international, Vol. 12, Issue 1, pp. 49, (2013) (PubMed).

Chen, Shi, Liu, Fang, Zhang, Zhao: "Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis." dans: BMC cancer, Vol. 12, pp. 464, (2012) (PubMed).

Yang, Gu, Zheng, Li, Lian, Miao, Jiang, Wei: "RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells." dans: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11865-74, (2011) (PubMed).

Détails sur p21

Antigène: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Autre désignation: CDKN1A

Sujet:

Synonyms: P21, CDKI, CIP1, SDI1, Waf1, mda6, CAP2, Cdkn1, p21WAF, p21Cip1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, Cdkn1a

Background: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).

ID gène: 12575

UniProt: P38936

Pathways: Signalisation p53, Signalisation PI3K-Akt, Cycle Cellulaire, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy