GRB2 anticorps (Cy7)

N° du produit ABIN686938

Cet anticorps Lapin Polyclonal détecte spécifiquement GRB2 dans IF (p). Il présente une réactivité envers Humain, Souris, Rat, Chien et Poulet.

Aperçu rapide pour GRB2 anticorps (Cy7) (ABIN686938)

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRB2 est conjugé à/à la Cy7

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-GRB2 anticorps (Cy7)

Specificité: Excitation / Emission Wavelengths: 743nm/767nm

Réactivité croisée: Rat (Rattus), Poulet, Chien

Purification: purified by Protein A

Immunogène: KLH conjugated synthetic peptide derived from human GRB2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.

Commentaires:

Excitation / Emission wavelength: 743nm / 767nm

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 4 °C for 12 months

Date de péremption: 12 months

Détails sur GRB2

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Autre désignation: GRB2/ASH

Sujet: Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.

Poids moléculaire: 25kDa

ID gène: 2885

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation