TNFRSF8 anticorps
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- Antigène Voir toutes TNFRSF8 Anticorps
- TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TNFRSF8 est non-conjugé
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Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. Its epitope is located between aa112-412. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin's disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
- Réactivité croisée (Details)
- Human.
- Immunogène
- Co cell line established from a patient with Hodgkin's disease of T-cell lineage
- Clone
- Ber-H2
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product TNFRSF8 Anticorps primaire
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- Indications d'application
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Known_Application: Immunohistochemistry (Formalin-fixed) (1:50-1:100 for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 7.5-8.5, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: Hodgkin's lymphoma.
- Restrictions
- For Research Use only
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- Buffer
- Tissue culture supernatant with 0.05% Azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Date de péremption
- 24 months
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- Antigène
- TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))
- Autre désignation
- TNFRSF8 (TNFRSF8 Produits)
- Synonymes
- anticorps CD30, anticorps D1S166E, anticorps Ki-1, anticorps Cd30, anticorps Ki, anticorps TNFRSF8, anticorps TNF receptor superfamily member 8, anticorps tumor necrosis factor receptor superfamily, member 8, anticorps TNFRSF8, anticorps Tnfrsf8
- Sujet
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CD30L receptor, Cytokine receptor CD30, Ki-1 antigen, Lymphocyte activation antigen CD30, Tumor necrosis factor receptor superfamily member 8 (TNFRSF8),CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker)
Cellular localisation: Cell surface - Poids moléculaire
- 105-120kDa
- ID gène
- 943, 1314
- UniProt
- P28908
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