BCMA anticorps (AA 78-184)

N° du produit ABIN6936646

Détail du produit anti-BCMA anticorps

Antigène: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Épitope: AA 78-184

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCMA est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant human CD269 protein fragment (around aa 78-184) (exact sequence is proprietary)

Clone: BCMA-2366

Isotype: IgG2c kappa

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: NAMALWA cells. Tonsil or gastric carcinoma (IHC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur BCMA

Antigène: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Autre désignation: CD269 (TNFRSF17 Produits)

Synonymes: anticorps TNFRSF17, anticorps BCM, anticorps BCMA, anticorps CD269, anticorps TNFRSF13A, anticorps Tnfrsf13, anticorps Tnfrsf13a, anticorps TNF receptor superfamily member 17, anticorps tumor necrosis factor receptor superfamily, member 17, anticorps Tnfrsf17, anticorps TNFRSF17

Sujet: B-cell maturation protein, BCMA, CD269, TNR17, Tumor necrosis factor receptor superfamily member 17 (TNFRSF17),CD269 / TNFRSF17 / BCMA (B-Cell Maturation Protein)
Cellular localisation: Cell Surface

Poids moléculaire: 20kDa

ID gène: 608, 2556

UniProt: Q02223