CD3 epsilon anticorps

N° du produit ABIN6936700

Cet anticorps anti-CD3 epsilon est un anticorps Souris Monoclonal détectant CD3 epsilon dans FACS, IHC, IF, Func et IHC (fro). Adapté pour Humain.

Aperçu rapide pour CD3 epsilon anticorps (ABIN6936700)

Antigène: CD3 epsilon (CD3E)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD3 epsilon est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: OKT3

Détail du produit anti-CD3 epsilon anticorps

Specificité: Recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28 kDa. It is found on all mature T-lymphocytes, NK, T-cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. It is expressed, typically at high levels, on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and, in cortical thymus, CD3 is predominantly Intracytoplasmic. This MAb has been reported to have potent immunosuppressive properties in vivo and has been proven effective in the treatment of renal, heart and liver allograft rejection.

Réactivité croisée (Details): Human. Others not known.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Human PBMC s

Isotype: IgG2a kappa

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (0.5-1 μg/million cells), ,Immunohistochemistry (acetone fixed frozen sections), ,Immunofluorescence (1-2 μg/mL), ,Functional Studies (Order Ab without Azide),Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat cells or PBMCs. Tonsil and lymph node

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur CD3 epsilon

Antigène: CD3 epsilon (CD3E)

Autre désignation: CD3E

Sujet: CD3 epsilon, CD3 TCR complex, CD3e antigen epsilon polypeptide (TiT3 complex), T cell antigen receptor complex epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, T3E,CD3e (T-Cell Marker)
Cellular localisation: Cell surface and cytoplasmic

Poids moléculaire: 23kDa

ID gène: 916, 3003

UniProt: P07766

Pathways: TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway