FCGR2A anticorps

N° du produit ABIN6937220

Détail du produit anti-FCGR2A anticorps

Antigène: FCGR2A (Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FCGR2A est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Functional Studies (Func)

Specificité: This MAb binds most strongly to the IIa isoforms of CD32 (FcRII), a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant human FCGR2A protein

Clone: FCGR2A-479

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Known_Application: Functional Studies (Order Ab without BSA & Azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: K-562 cells. Lymph node, tonsil and placenta.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur FCGR2A

Antigène: FCGR2A (Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A))

Autre désignation: FCGR2A (FCGR2A Produits)

Synonymes: anticorps CD32, anticorps CD32A, anticorps CDw32, anticorps FCG2, anticorps FCGR2, anticorps FCGR2A1, anticorps FcGR, anticorps IGFR2, anticorps CD32a, anticorps Fc fragment of IgG receptor IIa, anticorps FCGR2A

Sujet: CD32A, Fc fragment of IgG low affinity IIa receptor, Fc gamma RIIa, FCGR2A, FcgRII, IGFR2, IgG Fc receptor II-a, Low affinity immunoglobulin gamma Fc region receptor II-a, Ly-17, Ly-m20, LyM-1, Lymphocyte antigen 17,CD32 (Fc Gamma RIIa)
Cellular localisation: Cell Surface

Poids moléculaire: 40kDa

ID gène: 2212, 352642

UniProt: P12318