FCGR3A anticorps

N° du produit ABIN6937225

Détail du produit anti-FCGR3A anticorps

Antigène: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FCGR3A est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Specificité: It recognizes CD16 (FcgammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcgammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcgammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Human CD16 protein

Clone: ICO-116

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: K-562 or U-937 cells. Lymph nodes and tonsils.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur FCGR3A

Antigène: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Autre désignation: FCGR3A (FCGR3A Produits)

Synonymes: anticorps CD16, anticorps CD16A, anticorps FCG3, anticorps FCGR3, anticorps FCGRIII, anticorps FCR-10, anticorps FCRIII, anticorps FCRIIIA, anticorps IGFR3, anticorps Fcgr4, anticorps Fc fragment of IgG receptor IIIa, anticorps FCGR3A, anticorps Fcgr3a

Sujet: FcRIIIa; FCR-10; FcRIII; FCGRIII; FcR-10; Fc fragment of IgG, low affinity IIIa, receptor for (CD16); neutrophil-specific antigen NA; CD16a; low affinity immunoglobulin gamma Fc region receptor III-A; Fc-gamma RIIIa; immunoglobulin G Fc receptor III; Fc-gamma RIII-alpha; Fc-gamma receptor IIIb (CD16); CD16a antigen; Fc-gamma receptor III-2 (CD16); FCGR3; Fc gamma receptor III-A; FCG3; low affinity III, receptor for (CD16); Fc-gamma RIII; IGFR3FcgammaRIIIA; CD16FCRIIIA; FCRIII; Fc fragment of IgG, low affinity IIIa, receptor (CD16a),CD16 / FcγReceptor III
Cellular localisation: Cell Surface

Poids moléculaire: 50-80kDa

ID gène: 2214, 372679

UniProt: P08637