PPP3CA anticorps
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- Antigène Voir toutes PPP3CA Anticorps
- PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PPP3CA est non-conjugé
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Application
- Western Blotting (WB), ELISA, Coating (Coat)
- Specificité
- Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
- Réactivité croisée (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant full-length Calcineurin A protein
- Clone
- BF1-1
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product PPP3CA Anticorps primaire
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- Indications d'application
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Known_Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
- Autre désignation
- PPP3CA (PPP3CA Produits)
- Synonymes
- anticorps CALN, anticorps CALNA, anticorps CALNA1, anticorps CCN1, anticorps CNA1, anticorps PPP2B, anticorps 2900074D19Rik, anticorps AI841391, anticorps AW413465, anticorps CN, anticorps Caln, anticorps Calna, anticorps CnA, anticorps Calna1, anticorps calcineurin, anticorps caln, anticorps calna, anticorps calna1, anticorps ccn1, anticorps cna1, anticorps ppp2b, anticorps fj46e08, anticorps si:dkeyp-79c2.2, anticorps wu:fj46e08, anticorps ppp3ca, anticorps protein phosphatase 3 catalytic subunit alpha, anticorps protein phosphatase 3, catalytic subunit, alpha isoform, anticorps protein phosphatase 3, catalytic subunit, alpha isozyme, anticorps protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha), anticorps protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog, anticorps serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, anticorps PPP3CA, anticorps Ppp3ca, anticorps ppp3ca, anticorps ppp3ca.L, anticorps LOC100205420
- Sujet
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Calcineurin A alpha, Calcineurin A1, Calcineurin A, Calmodulin-dependent calcineurin A subunit alpha isoform, CALN, CALNA1, CAM-PRP catalytic subunit, CCN1, CNA alpha, CNA1, Ppp3ca, Protein phosphatase 2B catalytic subunit (PPP2B), Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform (PPP3CA),Calcineurin A / PPP3CA
Cellular localisation: Cytoplasmic and Cell Surface - Poids moléculaire
- 62kDa
- ID gène
- 5530, 435512
- UniProt
- Q08209
- Pathways
- Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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