SERPINB3 anticorps

N° du produit ABIN6938379

Détail du produit anti-SERPINB3 anticorps

Antigène: SERPINB3 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SERPINB3 est non-conjugé

Application: Western Blotting (WB)

Specificité: Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant human full-length SERPINB3 protein

Clone: CPTC-SERPINB3-2

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: U-2197, HaCaT, Squamous cells. Expressed in some hepatocellular carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur SERPINB3

Antigène: SERPINB3 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3))

Autre désignation: SERPINB3 (SERPINB3 Produits)

Synonymes: anticorps HsT1196, anticorps SCC, anticorps SCCA-1, anticorps SCCA-PD, anticorps SCCA1, anticorps T4-A, anticorps LEUPIN, anticorps PI11, anticorps SCCA-2, anticorps SCCA2, anticorps serpin family B member 3, anticorps serpin family B member 4, anticorps serpin B3, anticorps Somatic cell count, anticorps SERPINB3, anticorps SERPINB4, anticorps Serpinb3, anticorps LOC483954, anticorps SCC

Sujet: HsT1196, Protein T4 A, Protein T4-A, SCC, SCCA-PD, SCCA1, SCCAPD, Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 3, Serpin B3, SERPINB3, Squamous cell carcinoma antigen 1, T4 A, T4-A,Squamous Cell Carcinoma Antigen 1
Cellular localisation: Cytoplasm.

Poids moléculaire: 39kDa

ID gène: 6317, 227948

UniProt: P29508