Spastin anticorps
-
- Antigène Voir toutes Spastin (SPAST) Anticorps
- Spastin (SPAST)
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp Spastin est non-conjugé
-
Application
- Western Blotting (WB), Immunofluorescence (IF)
- Specificité
- The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40 % of all autosomal dominant HSPs.
- Réactivité croisée (Details)
- Human. Mouse. Rat.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant full-length human Spastin protein.
- Clone
- Sp 6C6
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product SPAST Anticorps primaire
-
-
- Indications d'application
-
Known_Application: Immunofluorescence (1-2 μg/mL), ,Western Blot (1-2 μg/mL),Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. K-562 or Raji cell lysates.
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
-
- Antigène
- Spastin (SPAST)
- Autre désignation
- SPAST (SPAST Produits)
- Synonymes
- anticorps CG5977, anticorps D-spastin, anticorps Dmel\\CG5977, anticorps Dspastin, anticorps Spas, anticorps zgc:85952, anticorps SPAST, anticorps spg4, anticorps LOC100224472, anticorps ADPSP, anticorps FSP2, anticorps SPG4, anticorps Spg4, anticorps mKIAA1083, anticorps spastin, anticorps spastin S homeolog, anticorps spas, anticorps spast, anticorps SPAST, anticorps Spast, anticorps spast.S
- Sujet
-
ADPSP, FSP2, Spast, Spatin, SPG4,Spastin
Cellular localisation: Cell Membrane and Secreted. - Poids moléculaire
- 52kDa
- ID gène
- 6683, 468091
- Pathways
- Dynamique des Microtubules, M Phase, Regulation of Cell Size
-