CGA anticorps

N° du produit ABIN6939100

Détail du produit anti-CGA anticorps

Antigène: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CGA est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM), Immunostaining (ISt)

Specificité: This MAb reacts with a protein of ~13 kDa, identified as alpha sub-unit of Luteinizing Hormone (LH). Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor, however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length hLH alpha protein

Clone: LHa-756

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: Anterior Pituitary.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(No special pre-treatment is required for staining of formalin-fixed tissues. Note that HIER is NOT recommended for this antibody.)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CGA

Antigène: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Autre désignation: LHA (CGA Produits)

Synonymes: anticorps CG-ALPHA, anticorps FSHA, anticorps GPHA1, anticorps GPHa, anticorps HCG, anticorps LHA, anticorps TSHA, anticorps CG-alpha, anticorps GPHalpha, anticorps Tsha, anticorps aGSU, anticorps alpha-GSU, anticorps alphaGSU, anticorps alphaSU, anticorps CGA, anticorps FSH-alpha, anticorps LSH-alpha, anticorps TSH-alpha, anticorps cg-alpha, anticorps cga, anticorps cga-a, anticorps cga-b, anticorps fsha, anticorps gpha, anticorps gpha1, anticorps hcg, anticorps lha, anticorps tsha, anticorps GTH-alpha, anticorps gsu-alpha, anticorps glycoprotein hormones, alpha polypeptide, anticorps glycoprotein hormones, alpha subunit, anticorps chromogranin A, anticorps glycoprotein hormones, alpha polypeptide L homeolog, anticorps CGA, anticorps Cga, anticorps CHGA, anticorps cga.L, anticorps cga

Poids moléculaire: ~13kDa

ID gène: 1081

UniProt: P01215

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport, Peptide Hormone Metabolism