G1/S-Specific B-Type Cyclin Cig2 (CIG2) anticorps

N° du produit ABIN6941328

Détail du produit

Antigène: G1/S-Specific B-Type Cyclin Cig2 (CIG2)

Reactivité: Schizosaccharomyces pombe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Coating (Coat), ELISA, Western Blotting (WB)

Purification: Purified by Protein A/G

Immunogène: Bacterial S. pombe Cig2 Purified protein.

Clone: 3A11-5

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: Red blood cell lysate, Human colon and lung tissue.

Known Application: ELISA (For coating, order antibody without BSA),Western Blot (0.5-1.0 μg/mL)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détail du antigène

Antigène: G1/S-Specific B-Type Cyclin Cig2 (CIG2)

Autre désignation: Cig2 (CIG2 Produits)

Synonymes: anticorps G1/S-specific B-type cyclin Cig2, anticorps cig2

Sujet: Cig2 is a cyclin that functions as the catalytic subunit of cyclin-dependent kinases (Cdks) in the fission yeast Schizosaccharomyces pombe. It is a B-type, S phase cyclin that is required for both the G1/S and G2/M cell cycle transitions and is expressed in a sharp spike that peaks during the G1/S period. Cig2 binds to Cdc2 (Cdk), and the resulting Cdc2/Cig2 complex controls the G1/S transition of the cell cycle. Disruption of Cig2 delays the onset of mitosis. The expression of the Cig2 gene is dependent on Mlu1-binding factor (MBF), and the protein is destroyed during anaphase by the APC/cyclosome (APC/C) and Skp1/Cullin-1/F-box (SCF), thereby ensuring the spike expression pattern of Cig2. SCF regulates Cig2 levels in a dual manner, transcriptionally and post-translationally, while APC/C only destroys the protein.

Poids moléculaire: 50kDa