Human Papilloma Virus 16, 18 E6 (HPV-16, HPV-18 E6) anticorps

N° du produit ABIN6933776

Détail du produit

Antigène: Human Papilloma Virus 16, 18 E6 (HPV-16, HPV-18 E6)

Reactivité: Human Papillomavirus 16 (HPV-16)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: ELISA, Coating (Coat)

Purification: Purified by Protein A/G

Immunogène: HPV18 E6-β-galactosidase fusion protein

Clone: HPV16-1295-HPV18-1297

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: Human cervical cancer cells. Cervical tissue.

Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détail du antigène

Antigène: Human Papilloma Virus 16, 18 E6 (HPV-16, HPV-18 E6)

Autre désignation: HPV-16 E6 + HPV-18 E6 (Human Papilloma Virus 16/18)

Classe de substances: Viral Protein

Sujet: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

Poids moléculaire: 16/17kDa