DIAPH1 anticorps

N° du produit ABIN6943002

Détail du produit anti-DIAPH1 anticorps

Antigène: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp DIAPH1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Recombinant protein corresponding to N-terminal human DIAPH1.

Clone: 1C11

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur DIAPH1

Antigène: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Autre désignation: DIAPH1 (DIAPH1 Produits)

Synonymes: anticorps DIAPH1, anticorps dia1, anticorps drf1, anticorps dfna1, anticorps diap1, anticorps lfhl1, anticorps DIAPH2, anticorps Diap1, anticorps D18Wsu154e, anticorps Dia1, anticorps Diaph1, anticorps Drf1, anticorps mKIAA4062, anticorps p140mDia, anticorps DFNA1, anticorps DIA1, anticorps DRF1, anticorps LFHL1, anticorps hDIA1, anticorps diaphanous related formin 1, anticorps diaphanous related formin 2, anticorps diaphanous-related formin 1, anticorps protein diaphanous homolog 1, anticorps DIAPH1, anticorps diaph1, anticorps DIAPH2, anticorps Diaph1, anticorps LOC100457442

Sujet:

Synonyms: Protein diaphanous homolog 1, Diaphanous-related formin-1, DRF1, DIAPH1, DIAP1

Background: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane. In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Plays a role in brain development. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.

ID gène: 1729

UniProt: O60610

Pathways: Sensory Perception of Sound