GBL anticorps (PE)

N° du produit ABIN6943497

Cet anticorps Lapin Polyclonal détecte spécifiquement GBL dans FACS. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour GBL anticorps (PE) (ABIN6943497)

Antigène: GBL (G protein beta subunit-like (GBL))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GBL est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-GBL anticorps (PE)

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human G protein beta subunit like

Isotype: IgG

Information d'application

Indications d'application: FCM(1:20-100)

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur GBL

Antigène: GBL (G protein beta subunit-like (GBL))

Autre désignation: G protein beta subunit like

Sujet:

Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.Tissue specificity:Broadly expressed, with highest levels in skeletal muscle, heart and kidney.

Synonyms: G protein beta subunit like, G protein beta subunit-like, Gable, GBL, GBL protein, LST8_HUMAN, Mammalian lethal with SEC13 protein 8, MGC111011, mLST8, Protein GbetaL, Target of rapamycin complex subunit LST8, TORC subunit LST8.

Pathways: Signalisation PI3K-Akt, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Autophagy, CXCR4-mediated Signaling Events, BCR Signaling, L'effet Warburg