IL12 anticorps (AA 141-200) (HRP)

N° du produit ABIN6943794

Cet anticorps Lapin Polyclonal détecte spécifiquement IL12 dans ELISA, WB, IHC (fro) et IHC (p). Il présente une réactivité envers Rat.

Aperçu rapide pour IL12 anticorps (AA 141-200) (HRP) (ABIN6943794)

Antigène: IL12 (Interleukin 12 (IL12))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL12 est conjugé à/à la HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IL12 anticorps (HRP)

Épitope: AA 141-200

Réactivité croisée: Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from rat IL-12

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur IL12

Antigène: IL12 (Interleukin 12 (IL12))

Autre désignation: IL-12

Sujet:

Synonyms: IL12, IL-12, CLMF p35, CLMF1, CTL maturation factor (TcMF), Cytotoxic lymphocyte maturation factor 1, Cytotoxic lymphocyte maturation factor 35 kDa subunit, IL 12 subunit p35, IL12A, Interleukin 12 alpha chain, Interleukin 12 p35, Interleukin 12A, Natural killer cell stimulatory factor 1, CLMF, CLMF p35, Cytotoxic lymphocyte maturation factor 35 kDa subunit, IL-12 subunit p35, IL-12A, IL12 subunit p35, IL12A, IL12A_HUMAN, Interleukin 12 p35, Interleukin 12A, Interleukin-12 subunit alpha, NFSK, NK cell stimulatory factor chain 1, NKSF1. NK cell stimulatory factor chain 1, NKSF1, p35, IL12A_RAT.

Background: IL-12 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

ID gène: 84405

UniProt: P29459

Pathways: Signalistation JAK/STAT, Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome