MEIS2 anticorps

N° du produit ABIN6944067

Détail du produit anti-MEIS2 anticorps

Antigène: MEIS2 (Meis Homeobox 2 (MEIS2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MEIS2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris

Purification: Purified by Protein A.

Immunogène: Recombinant protein within human MEIS2 aa 1-200

Clone: 3C2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur MEIS2

Antigène: MEIS2 (Meis Homeobox 2 (MEIS2))

Autre désignation: MEIS2 (MEIS2 Produits)

Synonymes: anticorps HsT18361, anticorps MRG1, anticorps A430109D20Rik, anticorps Mrg1, anticorps Stra10, anticorps Meis2a.1, anticorps Meis2a.2, anticorps mrg1, anticorps MEIS2, anticorps hst18361, anticorps DKFZp469A1832, anticorps fa26d08, anticorps meis2.2, anticorps wu:fa26d08, anticorps meis2, anticorps meis2.1, anticorps Meis homeobox 2, anticorps Meis homeobox 2 L homeolog, anticorps Meis homeobox 2a, anticorps Meis homeobox 2b, anticorps MEIS2, anticorps Meis2, anticorps meis2.L, anticorps meis2, anticorps meis2a, anticorps meis2b

Sujet:

Synonyms: Homeobox protein Meis2, Meis1-related protein 1, MEIS2, MRG1

Background: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element, MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3', in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription, isoform 5 cannot activate DRD1 transcription.

ID gène: 4212

UniProt: O14770