SRP54 anticorps

N° du produit ABIN6945061

Détail du produit anti-SRP54 anticorps

Antigène: SRP54 (Signal Recognition Particle 54kDa (SRP54))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SRP54 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein within human SRP54 aa 1-200.

Clone: 1A4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IP(1-2 μg)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SRP54

Antigène: SRP54 (Signal Recognition Particle 54kDa (SRP54))

Autre désignation: SRP54 (SRP54 Produits)

Synonymes: anticorps Srp54k, anticorps zgc:55842, anticorps zgc:85713, anticorps SRP54, anticorps signal recognition particle 54, anticorps signal recognition particle protein, anticorps signal recognition particle subunit Srp54, anticorps signal recognition particle, anticorps family with sequence similarity 177 member A1, anticorps signal recognition particle 54kDa S homeolog, anticorps signal recognition particle 54kDa, anticorps SRP54, anticorps srp54, anticorps SSO_RS04840, anticorps MA_RS23935, anticorps AF_RS03170, anticorps PAB_RS02540, anticorps MSP_RS07670, anticorps RCI_RS04175, anticorps TGAM_RS09885, anticorps MTBMA_RS08340, anticorps FAM177A1, anticorps srp54.S, anticorps Srp54

Sujet:

Synonyms: Signal recognition particle 54 kDa protein, SRP54

Background: SRP54, a component of the signal recognition particle (SRP), recognizes the signal peptide of secretory proteins and interacts with the signal recognition particle receptor to target the ribosome and the associated nascent chain to the endoplasmic reticulum. By functional analysis showed that SRP54 binds to SRP RNA via the M-domain, but only in the presence of RNA-bound SRP19, and that it associates with the signal peptide of nascent polypeptide chains. RNA interaction requires the presence of a loop in the C-terminal M-domain. Signal peptide recognition most likely involves methionine-rich loops. During signal peptide recognition, SRP54 is positioned at the exit site close to ribosomal proteins L23a and L35. When SRP54 contacts the signal recognition particle receptor, SRP54 is rearranged such that it is no longer close to L23a. This repositioning may allow the translocon to dock with the ribosome, leading to insertion of the signal peptide into the translocation channel.

ID gène: 6729

UniProt: P61011

Pathways: SARS-CoV-2 Protein Interactome