IL-1 beta anticorps

N° du produit ABIN6963831

L’anticorps Souris Monoclonal anti-IL-1 beta a été validé pour ELISA et ELISpot. Il convient pour détecter IL-1 beta dans des échantillons de Humain. Il y a 4+ publications disponibles.

Aperçu rapide pour IL-1 beta anticorps (ABIN6963831)

Antigène: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-1 beta est non-conjugé

Application: ELISA, ELISpot

Clone: MT175

Détail du produit anti-IL-1 beta anticorps

Specificité: Native and recombinant human IL-1β. The antibody binds to the pro-form and active form of IL-1β. No cross-reactivity with IL-1α.

Réactivité croisée (Details): This monoclonal antibody enables sensitive and specific detection of human IL-1β in immunoassays such as ELISA and ELISpot. The antibody binds to the pro-form and the active form of IL-1β. It does not cross-react with IL-1α.

Purification: Purified from in vitro cultures by protein G affinity chromatography.

Stérilité: 0.2 μm filtered

Immunogène: Recombinant human IL-1beta

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: supplied at 0.5 mg/mL in PBS with 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Date de péremption: 18 months

Références pour anticorps anti-IL-1 beta (ABIN6963831)

Lang, Lee, Elgass, Pinar, Tate, Aitken, Fan, Creed, Deen, Traore, Mueller, Stanisic, Baiwog, Skene, Wilce, Mansell, Morand, Harris: "Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation." dans: Nature communications, Vol. 9, Issue 1, pp. 2223, (2018) (PubMed).

Chen, Messina, Germano, Bonnici, Freyne, Cheung, Goldsmith, Kollmann, Levin, Burgner, Curtis: "Innate immune responses following Kawasaki disease and toxic shock syndrome." dans: PLoS ONE, Vol. 13, Issue 2, pp. e0191830, (2018) (PubMed).

Palizgir, Akhtari, Mahmoudi, Mostafaei, Rezaiemanesh, Shahram: "Curcumin reduces the expression of interleukin 1β and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet's disease." dans: Immunopharmacology and immunotoxicology, Vol. 40, Issue 4, pp. 297-302, (2018) (PubMed).

Gille-Johnson, Smedman, Gudmundsdotter, Somell, Nihlmark, Paulie, Andersson, Gårdlund: "Circulating monocytes are not the major source of plasma cytokines in patients with sepsis." dans: Shock (Augusta, Ga.), Vol. 38, Issue 6, pp. 577-83, (2013) (PubMed).

Détails sur IL-1 beta

Antigène: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Autre désignation: IL1B

ID gène: 3553

Pathways: Signalisation NF-kappaB, Interferon-gamma Pathway, Signalisation TLR, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome