IL-1 beta anticorps (Biotin)

N° du produit ABIN6963832

Cet anticorps anti-IL-1 beta est un anticorps Souris Monoclonal détectant IL-1 beta dans ELISA et ELISpot. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour IL-1 beta anticorps (Biotin) (ABIN6963832)

Antigène: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-1 beta est conjugé à/à la Biotin

Application: ELISA, ELISpot

Clone: 7P10

Détail du produit anti-IL-1 beta anticorps (Biotin)

Specificité: Native and recombinant human IL-1β. The antibody binds to the pro-form and active form of IL-1β. No cross-reactivity with IL-1α.

Réactivité croisée (Details): This monoclonal antibody enables sensitive and specific detection of human IL-1β in immunoassays such as ELISA and ELISpot. The antibody binds to the pro-form and the active form of IL-1β. It does not cross-react with IL-1α.

Attributs du produit: This monoclonal antibody enables specific detection of human IL-1β in immunoassays such as ELISpot, FluoroSpot, and ELISA. Serum/Plasma samples

Purification: Biotinylated through reaction with a N-hydroxysuccinimide ester of biotin.,Purified from in vitro cultures by protein G affinity chromatography.

Stérilité: 0.2 μm filtered

Immunogène: Recombinant human IL-1beta

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

ABIN6963832 and ABIN7448283 is recommended as detection mAb in ELISpot, FluoroSpot, and ELISA in combination with capture mAb ABIN6963831 and ABIN7448282 .

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: supplied at 0.5 mg/mL in PBS with 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Date de péremption: 18 months

Références pour anticorps anti-IL-1 beta (Biotin) (ABIN6963832)

Palizgir, Akhtari, Mahmoudi, Mostafaei, Rezaiemanesh, Shahram: "Curcumin reduces the expression of interleukin 1β and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet's disease." dans: Immunopharmacology and immunotoxicology, Vol. 40, Issue 4, pp. 297-302, (2018) (PubMed).

Lang, Lee, Elgass, Pinar, Tate, Aitken, Fan, Creed, Deen, Traore, Mueller, Stanisic, Baiwog, Skene, Wilce, Mansell, Morand, Harris: "Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation." dans: Nature communications, Vol. 9, Issue 1, pp. 2223, (2018) (PubMed).

Chen, Messina, Germano, Bonnici, Freyne, Cheung, Goldsmith, Kollmann, Levin, Burgner, Curtis: "Innate immune responses following Kawasaki disease and toxic shock syndrome." dans: PLoS ONE, Vol. 13, Issue 2, pp. e0191830, (2018) (PubMed).

Gille-Johnson, Smedman, Gudmundsdotter, Somell, Nihlmark, Paulie, Andersson, Gårdlund: "Circulating monocytes are not the major source of plasma cytokines in patients with sepsis." dans: Shock (Augusta, Ga.), Vol. 38, Issue 6, pp. 577-83, (2013) (PubMed).

Détails sur IL-1 beta

Antigène: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Autre désignation: IL1B

ID gène: 3553

Pathways: Signalisation NF-kappaB, Interferon-gamma Pathway, Signalisation TLR, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome