SMARCA4 anticorps (AA 213-295)

N° du produit ABIN6972735

Détail du produit anti-SMARCA4 anticorps

Antigène: SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))

Épitope: AA 213-295

Reactivité: Humain, Souris, Singe

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp SMARCA4 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Attributs du produit: SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) is the central catalytic ATPase subunit of numerous chromatin-remodeling complexes, including SWI/SNF. These complexes are able to use energy from ATP hydrolysis to physically disrupt chromatin architecture of target promoters and facilitate the binding of transcription factors to nucleosomal DNA. SMARCA4 is a co-regulator of transcription and has been implicated in the activation and repression of gene expression through the modulation of chromatin in various tissues and physiological conditions. This protein plays a major role in many cellular processes such as DNA replication, repair and recombination. Mammalian SMARCA4 is usually associated with approximately 10-12 BAF subunits or other proteins involved in regulation of gene expression. SMARCA4 is part of the stem cell-specific BAF complex, esBAF, and is involved in regulating stem cell pluripotency. SMARCA4 antibody (mAb) (Clone 5B7) was raised in a Rat host. It has been validated for use in Immunocytochemistry, Immunofluorescence and Western blot, it has been shown to react with Human, Monkey and Mouse samples.

Purification: Protein G Chromatography

Immunogène: This antibody was raised against a recombinant protein corresponding to amino acids 213-295 of human SMARCA4.

Clone: 5B7

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur SMARCA4

Antigène: SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))

Autre désignation: SMARCA4 (SMARCA4 Produits)

Synonymes: anticorps SMARCA4, anticorps BAF190, anticorps BAF190A, anticorps BRG1, anticorps MRD16, anticorps RTPS2, anticorps SNF2, anticorps SNF2L4, anticorps SNF2LB, anticorps SWI2, anticorps hSNF2b, anticorps brg-1, anticorps Brg1, anticorps HP1-BP72, anticorps SNF2beta, anticorps SW1/SNF, anticorps b2b692Clo, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, anticorps SMARCA4, anticorps Smarca4

Poids moléculaire: 180 kDa

NCBI Accession: NP_001122321

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance