IL4 Receptor anticorps (AA 171-270) (AbBy Fluor® 555)

N° du produit ABIN6978822

Cet anticorps anti-IL4 Receptor est un anticorps Lapin Polyclonal détectant IL4 Receptor dans WB, IF (p) et IF (cc). Adapté pour Humain.

Aperçu rapide pour IL4 Receptor anticorps (AA 171-270) (AbBy Fluor® 555) (ABIN6978822)

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL4 Receptor est conjugé à/à la AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-IL4 Receptor anticorps (AbBy Fluor® 555)

Épitope: AA 171-270

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IL-4R

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur IL4 Receptor

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Autre désignation: IL-4R

Sujet:

Synonyms: Interleukin-4 Receptor, 582J2.1, CD124, CD-124, CD 124, IL 4R alpha, IL4RA, Interleukin 4 receptor alpha chain, MGC118473.

Background: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].

ID gène: 3566

UniProt: P24394

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process