JAK1 anticorps (Cy5)

N° du produit ABIN6984861

Cet anticorps anti-JAK1 est un anticorps Souris Monoclonal détectant JAK1 dans IF (cc). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour JAK1 anticorps (Cy5) (ABIN6984861)

Antigène: JAK1 (Janus Kinase 1 (JAK1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JAK1 est conjugé à/à la Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 9G7

Détail du produit anti-JAK1 anticorps (Cy5)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G.

Immunogène: KLH conjugated synthetic peptide derived from human JAK1

Isotype: IgG

Information d'application

Indications d'application: IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur JAK1

Antigène: JAK1 (Janus Kinase 1 (JAK1))

Autre désignation: JAK1

Sujet:

Synonyms: JAK 1, JAK 1A, JAK 1B, JAK1, JAK1A, JAK1B, Janus kinase 1 (a protein tyrosine kinase), Janus kinase 1, JTK3, Tyrosine protein kinase JAK 1, Tyrosine protein kinase JAK1, JAK1_HUMAN.

Background: Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

ID gène: 3716

UniProt: P23458

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response