SMARCC1 anticorps (AA 301-400)

N° du produit ABIN6989262

Détail du produit anti-SMARCC1 anticorps

Antigène: SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))

Épitope: AA 301-400

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMARCC1 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SMARCC1

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SMARCC1

Antigène: SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))

Autre désignation: SMARCC1 (SMARCC1 Produits)

Synonymes: anticorps smarcc1, anticorps MGC53976, anticorps BAF155, anticorps CRACC1, anticorps Rsc8, anticorps SRG3, anticorps SWI3, anticorps AI115498, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 L homeolog, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1, anticorps smarcc1.L, anticorps smarcc1a, anticorps SMARCC1, anticorps Smarcc1

Sujet:

Synonyms: AI115498, BAF 155, BAF155, BRG 1 associated factor 155, BRG1 associated factor 155, BRG1-associated factor 155, Chromatin remodeling complex BAF155 subunit, CRACC 1, CRACC1, Mammalian chromatin remodeling complex BRG 1 associated factor 155, Mammalian chromatin remodeling complex BRG1 associated factor 155, Rsc 8, Rsc8, SMARC C1, SMARCC 1, SMARCC1, SMRC1_HUMAN, SRG 3, SRG3, SWI 3, SWI/SNF complex 155 kDa subunit, SWI/SNF complex subunit SMARCC1, SWI/SNF related matrix associated actin dependent regulator of chromatin c1, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1, SWI3.

Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

ID gène: 601732

UniProt: Q92922

Pathways: Chromatin Binding