TLR4 anticorps (C-Term)

N° du produit ABIN6990422

L’anticorps Lapin Polyclonal anti-TLR4 a été validé pour ELISA et IHC (p). Il convient pour détecter TLR4 dans des échantillons de Humain.

Aperçu rapide pour TLR4 anticorps (C-Term) (ABIN6990422)

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR4 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TLR4 anticorps

Épitope: C-Term

Specificité: TLR4 antibody is predicted to not cross-react with other TLR protein family members.

Purification: TLR4 Antibody is affinity chromatography purified via peptide column.

Immunogène: TLR4 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TLR4. The immunogen is located within the last 50 amino acids of TLR4.

Isotype: IgG

Information d'application

Indications d'application: TLR4 antibody can be used for detection of TLR4 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TLR4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TLR4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TLR4

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Autre désignation: TLR4

Sujet: TLR4 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κ,B. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

ID gène: 7099

NCBI Accession: NP_612564

UniProt: O00206

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins