MCL-1 anticorps (AA 110-160)

N° du produit ABIN6990528

Cet anticorps anti-MCL-1 Polyclonal Lapin (ABIN6990528) détecte spécifiquement MCL-1 dans WB, ELISA et ICC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MCL-1 anticorps (AA 110-160) (ABIN6990528)

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCL-1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-MCL-1 anticorps

Épitope: AA 110-160

Specificité: Detects isoforms Mcl-1L and Mcl-1S

Purification: Mcl-1 Antibody is Ion exchange chromatography purified.

Immunogène: Mcl-1 antibody was raised against a peptide corresponding to 16 amino acids near the center of human Mcl-1. The immunogen is located within amino acids 110 - 160 of Mcl-1.

Isotype: IgG

Information d'application

Indications d'application: Mcl-1 antibody can be used for detection of isoforms Mcl-1L and Mcl-1S by Western blot at 0.5 to 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Mcl-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Mcl-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur MCL-1

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Autre désignation: Mcl-1

Sujet: Mcl-1 Antibody: Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least three distinct isoforms designated Mcl-1L, Mcl-1S and Mcl-1ES. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

ID gène: 4170

NCBI Accession: NP_068779

UniProt: Q07820

Pathways: Signalisation MAPK