IFNB1 anticorps (AA 110-160)

N° du produit ABIN6990615

Cet anticorps anti-IFNB1 Polyclonal Lapin (ABIN6990615) détecte spécifiquement IFNB1 dans WB, ELISA, IHC (p) et IF. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour IFNB1 anticorps (AA 110-160) (ABIN6990615)

Antigène: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFNB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-IFNB1 anticorps

Épitope: AA 110-160

Purification: IFN-beta Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-IFN-beta antibody was raised against a peptide corresponding to 17 amino acids near the center of human IFN-beta. The immunogen is located within amino acids 110-160 of IFN-beta.

Isotype: IgG

Information d'application

Indications d'application: WB: 4-10 μ,g/mL, IHC: 2.5 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IFN-beta Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IFN-beta antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur IFNB1

Antigène: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Autre désignation: IFN-beta

Sujet: IFN-beta Antibody: Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

Poids moléculaire: Predicted: 22kD

Observed: 22kD. kDa

ID gène: 3456

UniProt: P01574

Pathways: Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome