SLUG anticorps (AA 70-120)
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- Antigène Tous les produits SLUG
- SLUG
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Épitope
- AA 70-120
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SLUG est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- Slug Antibody is affinity chromatography purified via peptide column.
- Immunogène
- Slug antibody was raised against a 14 amino acid synthetic peptide from near the center of human Slug. The immunogen is located within amino acids 70 - 120 of Slug.
- Isotype
- IgG
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- Indications d'application
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Slug antibody can be used for detection of Slug by Western blot at 1 to 2 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Slug Antibody is supplied in PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,4 °C
- Stockage commentaire
- Slug antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Antigène
- SLUG
- Abstract
- SLUG Produits
- Synonymes
- anticorps Slug, anticorps Slugh, anticorps Snail2, anticorps SLUG, anticorps SLUGH, anticorps SLUGH1, anticorps SNAIL2, anticorps WS2D, anticorps snail family zinc finger 2, anticorps snail family transcriptional repressor 2, anticorps Snai2, anticorps SNAI2
- Sujet
- Slug Antibody: Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
- ID gène
- 6591
- UniProt
- O43623
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