TBC1D1 anticorps (C-Term)

N° du produit ABIN6990756

Détail du produit anti-TBC1D1 anticorps

Antigène: TBC1D1 (TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBC1D1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: TBC1D1 Antibody is affinity chromatography purified via peptide column.

Immunogène: TBC1D1 antibody was raised against a 22 amino acid synthetic peptide from near the carboxy terminus of human TBC1D1. The immunogen is located within the last 50 amino acids of TBC1D1.

Isotype: IgG

Information d'application

Indications d'application: TBC1D1 antibody can be used for detection of TBC1D1 by Western blot at 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TBC1D1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TBC1D1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TBC1D1

Antigène: TBC1D1 (TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1))

Autre désignation: TBC1D1 (TBC1D1 Produits)

Synonymes: anticorps TBC1D1, anticorps TBC, anticorps TBC1, anticorps 1110062G02Rik, anticorps AI385682, anticorps AW555803, anticorps Tbc1, anticorps mKIAA1108, anticorps TBC1 domain family member 1, anticorps TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1, anticorps TBC1 domain family, member 1, anticorps TBC1D1, anticorps tbc1d1, anticorps LOC100523386, anticorps Tbc1d1

Sujet: TBC1D1 Antibody: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.

Poids moléculaire: Predicted: 128 kDa

Observed: 140 kDa 

ID gène: 23216

NCBI Accession: NP_055988

UniProt: Q86TI0